Journal of Pediatric Psychology 12(3) pp. 395-411, 1987
© 1987 Society of Pediatric Psychology
research-article |
Postirradiation Treatment Outcomes for Children with Acute Lymphocytic Leukemia: Clarification of Risks1
McGill University and the McGill-Montreal Children's Hospital Learning Centre, Children Hospital of Pittsburgh
2All correspondence should be sent to H. Gerry Taylor, McGill-Montreal Children's Hospital Learning Centre, 3640 Mountain Street, Montreal, Quebec H3G2A8
Developmental and educational consequences of treatment for acute lymphocytic leukemia (ALL) were examined in a group of 26 elementary school children who were survivors of the disease. All of the survivors had received cranial irradiation as part of their treatment. Risks were assessed by comparing each ALL survivor to one normal sibling on a comprehensive battery of tests and on measures of behavior and school performance. Consistent with previous findings, the ALL group performed less well than their siblings on tests of IQ, neuropsychological skills, and academic achievement. Analysis of ratings by parents and teachers revealed that the ALL group was less able to meet the academic demands of school but did not differ from the sibling group in behavioral adjustment. A greater number of children from the ALL group obtained borderline to low-average full-scale IQ scores; and more received special educational assistance at school. However, none of these children met criteria for mental retardation. The present findings help to clarify the risks associated with treatment protocols that include prophylac tic irradiation.
Key words: acute lymphocytic leukemia; intelligence; achievement; development; child neuropsychology.
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