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Journal of Pediatric Psychology 13(2) pp. 223-236, 1988
© 1988 Society of Pediatric Psychology

research-article

Electrophysiological Signs of Neurocognitive Deficits in Long-Term Leukemia Survivors1

Carol Heukrodt, Morris Powazek, Warren S. Brown2, Denise Kennelly, Charles Imbus, Herb Robinson and Stacy Schantz

School of Psychology Fuller Theological Seminary, Pasadena, Division of Pediatrics City of Hope National Medical Center, Duarte, California, School of Psychology Fuller Theological Seminary, Pasadena, Division of Pediatrics City of Hope National Medical Center, Duarte, California, School of Psychology Fuller Theological Seminary, Pasadena

2 All correspondence should be sent to Warren S. Brown, Graduate School of Psychology, Fuller Theological Seminary, 180 N. Oakland Avenue, Pasadena, California 91182

The long-term effects of disease and treatment on electrophysiological measures of neurocognitive function were studied in children who had survived acute lymphoblastic leukemia (ALL) for at least 4 years and were currently in remission. We report here changes in cognitive processing time as shown by the latency of the P3 wave of the auditory event-related EEG potential (ERP). P3 latency was significantly prolonged in long-term ALL surivors, as well as in patients successfully trreated for solid tumors(ST) outside the CNS who received similar chemotherapy but did not receive prophylactic treatment to the CNS. P3 latencies were strongly correlated with measures of school performance and IQ in these individuals. The similarity in P3 latency between the ALL and ST groups suggests that the treatments used on these pateints produce changes in electrophysiological responses that are associated with mild, but significant, cognitive deficits.

Key words: leukemia; learning disabilities; evoked potentials; P300; neuropsychological assessment.


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