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Journal of Pediatric Psychology 15(1) pp. 105-122, 1990
© 1990 Society of Pediatric Psychology

research-article

Sex Differences in Cognitive Processing in Children Treated with CNS Prophylaxis for Acute Lymphoblastic Leukemia1

Deborah P. Waber2, Gerald Gioia, Jeanne Paccia, Barbara Sherman, David Dinklage, Natalie Sollee, David K. Urion, Nancy J. Tarbell and Stephen E. Sallan

The Children's Hospital Boston

2 All correspondence should be sent to Deborah Waber, Department of Psychiatry, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02113

Evaluated cognitive processing in 51 children (27 female, 24 male) who had been treated for acute lymphoblastic leukemia (ALL) with CNS prophylaxis (cranial radiation in combination with intrathecal chemotherapy) and were continuously disease-free for 5 to 12 years. The control group comprised 15 children treated for Wilm's tumor. Functions assessed included visuopercep-tual skills, generation of organizational strategies, sensitivity to organizational structure, and attention. The ALL group showed performance deficits relative to the solid tumor controls in appreciating the organization inherent in complex visuospatial material and alertness, with females more severely affected than males. Sex differences favoring males on IQ and academic achievement were related to these cognitive processes.

Key words: cognitive processes; acute lymphoblastic leukemia; sex; IQ; academic achievement.


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