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Journal of Pediatric Psychology 16(1) pp. 13-26, 1991
© 1991 Society of Pediatric Psychology

research-article

Parental Report of Everyday Cognitive Abilities Among Children Treated For Acute Lymphoblastic Leukemia1

Kelli S. Williams, Judith Ochs, J. Michael Williams2 and Raymond K. Mulhern

MaGee Rehabilitation Hospital, St. Jude Children's Research Hospital, Hahnemann University School of Medicine, St. Jude Children's Research Hospital

2All correspondence should be sent to J. Michael Williams, Department of Mental Health Sciences, Mail Stop 341, Hahnemann University, Philadelphia, Pennsylvania 19102.

Compared ratings of everyday cognitive functioning made by parents of leukemic children to ratings made by parents of normal control and learning disabled (LD) children. The leukemic children had been randomly assigned to one of two CNS prophylaxis treatments, one including cranial irradiation and intrathecal methotrexate and another including only intrathecal methotrexate and intermediate dose infusions of methotrexate. Leukemic children were rated significantly worse than controls in areas related to schooling and academic skills. The type of CNS prophylaxis was not discriminated by parent ratings. LD children were rated as significantly worse than either of the two groups in all areas of cognitive functioning. Leukemic and LD children were both rated as having poor academ-ic skills. Leukemic children missed significantly more school than control and LD children, and their poor ratings on academic skills were partially attributed to academic deprivation. These results suggest that studies should control for academic deprivation when evaluating the neuropsychological outcome of CNS prophylactic treatment and that reintegration and normalization programs should be designed to address the intellectual problems resulting from missed academic experiences.

Key words: cognitive ability; leukemia; learning disability; CNS prophylaxis treatment.


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