Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (73)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Rovet, J. F.
Right arrow Articles by Sorbara, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rovet, J. F.
Right arrow Articles by Sorbara, D. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Pediatric Psychology 17(2) pp. 187-213, 1992
© 1992 Society of Pediatric Psychology

research-article

Neurodevelopment in Infants and Preschool Children with Congenital Hypothyroidism: Etiological and Treatment Factors Affecting Outcome1

Joanne F. Rovet2, Robert M. Ehrlich and Donna L. Sorbara

The Hospital for Sick Children Toronto, Canada

2All correspondence should be sent to Joanne F. Rovet, Department of Psychology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.

Studied global intelligence and specific abilities of children from 1 to 5 years old, 108 with congenital hypothyroidism (CH) diagnosed by newborn screening and 71 sibling controls. Intelligence levels of the CH group were within the normal range but differed significantly from controls at age 5. CH demonstrated a language deficit at age 3, which diminished with age, as well as significantly poorer visuospatial and verbal skills at age 5. Children with absent thyroid glands or evidence of hypothyroidism in utero were outperformed by other CH children in most ability areas from 1 year on. Different components of ability were correlated with specific factors reflecting timing or duration of thyroid hormone deficiency, suggesting unique critical periods of thyroid hormone sensitivity for different specific cognitive abilities and their neural substrates. It is concluded that even though screened CH children are markedly improved by neonatal diagnosis, they are still at risk for subtle irreversible deficits, which depend on factors such as type, age at onset, and duration of disease.

Key words: children; congenital hypothyroidism; newborn screening; selective deficits; thyroid hormone; treatment; risk factors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Pediatr. Rev.Home page
D. Counts and S. K. Varma
Hypothyroidism in Children
Pediatr. Rev., July 1, 2009; 30(7): 251 - 258.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. van der Sluijs Veer, M. J. E. Kempers, B. F. Last, T. Vulsma, and M. A. Grootenhuis
Quality of Life, Developmental Milestones, and Self-Esteem of Young Adults with Congenital Hypothyroidism Diagnosed by Neonatal Screening
J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2654 - 2661.
[Abstract] [Full Text] [PDF]

Home page
 J Pediatr PsycholHome page
B. S. Aylward, M. C. Roberts, J. Colombo, and R. G. Steele
Identifying the Classics: An Examination of Articles Published in the Journal of Pediatric Psychology from 1976-2006
J. Pediatr. Psychol., July 1, 2008; 33(6): 576 - 589.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. J. E. Kempers, L. van der Sluijs Veer, M. W. G. Nijhuis-van der Sanden, L. Kooistra, B. M. Wiedijk, I. Faber, B. F. Last, J. J. M. de Vijlder, M. A. Grootenhuis, and T. Vulsma
Intellectual and Motor Development of Young Adults with Congenital Hypothyroidism Diagnosed by Neonatal Screening
J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 418 - 424.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. F. Rovet
Children With Congenital Hypothyroidism and Their Siblings: Do They Really Differ?
Pediatrics, January 1, 2005; 115(1): e52 - e57.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Hanukoglu, K. Perlman, I. Shamis, L. Brnjac, J. Rovet, and D. Daneman
Relationship of Etiology to Treatment in Congenital Hypothyroidism
J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 186 - 191.
[Abstract] [Full Text]

Home page
 PediatricsHome page
J. F. Rovet and R. Ehrlich
Psychoeducational Outcome in Children With Early-Treated Congenital Hypothyroidism
Pediatrics, March 1, 2000; 105(3): 515 - 522.
[Abstract] [Full Text]

Home page
 Arch Intern MedHome page
A. T. Dugbartey
Neurocognitive Aspects of Hypothyroidism
Arch Intern Med, July 13, 1998; 158(13): 1413 - 1418.
[Abstract] [Full Text]

Home page
 Toxicol Ind HealthHome page
P. Hauser, J. M. McMillin, and V. S. Bhatara
Resistance To Thyroid Hormone: Implications for Neurodevelopmental Research On the Effects of Thyroid Hormone Disruptors
Toxicology and Industrial Health, January 1, 1998; 14(1-2): 85 - 101.
[Abstract] [PDF]

Home page
 Toxicol Ind HealthHome page
E. S. Sher, Xiao Ming Xu, P. M. Adams, C. M. Craft, and S. A. Stein
The Effects of Thyroid Hormone Level and Action in Developing Brain: Are These Targets for the Actions of Polychlorinated Biphenyls and Dioxins?
Toxicology and Industrial Health, January 1, 1998; 14(1-2): 121 - 158.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.