Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sirois, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sirois, P. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Pediatric Psychology 23(1) pp. 45-56, 1998
© 1998 Society of Pediatric Psychology

research-article

Hemophilia Growth and Development Study: Relationships Between Neuropsychological, Neurological, and MRI Findings at Baseline

Patricia A. Sirois, PhD1,8, Dale W. Usner, MS2, Suzanne D. Hill, PhD1, Wendy G. Mitchell, MD3, James F. Bale, Jr., MD4, Katherine A. Loveland, PhD5, James A. Stehbens, PhD4, Sharyne M. Donfield, PhD2, Margaret A. Maeder, MHS2, Nancy Amodei, PhD6, Charles F. Contant, Jr.,, PhD7, Marvin D. Nelson, Jr.,, MD3, John K. Willis, MD1 and Hemophilia Growth and Development Study

1Tulane University Medical Center Houston, 2New England Research Institutes, Inc. Houston, 3Childrens Hospital Los Angeles Houston, 4University of Iowa Hospitals and Clinics Houston, 5University of Texas Medical School Houston, 6University of Texas Health Science Center San Antonio, 7Baylor College of Medicine

8All correspondence should be sent to Patricia A. Sirois, Section ofHematol-ogy/Medical Oncology (SL-78), Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112. E-mail: psirois{at}tmcpop.tmc.tulane.edu

Objective: To determine the effects of human immunodeficiency virus (HIV) infection on children's development by identifying neurological and environmental variables associated with neuropsychological measures of cognitive development in HIV-seronegative (HIV–) and HIV-seropositive (HIV+) children and adolescents with hemophilia.

Methods: Participants (N = 298; 60% HIV+) were males ages 7—19 years enrolled in the Hemophilia Growth and Development Study (HGDS). Least squares modeling was used to determine whether there was a difference at baseline in mean neuropsychological test scores by HIV status, age, and neurological baseline findings, adjusting for selected environmental and medical history variables.

Results: The participants were within age expectations for general intelligence. Variables associated with lowered neuropsychological performance included academic problems, coordination and/or gait abnormalities, parents' education, and previous head trauma.

Conclusions: Hemophilia-related morbidity has a subtle adverse influence on cognitive performance. HIV infection was not associated with neuropsychological dysfunction in this group even when MRI abnormalities were present.

Key words: human immunodeficiency virus (HIV); hemophilia; child development; neuropsychology; neurology; MRI.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Pediatr PsycholHome page
P. A. Sirois, M. Posner, J. A. Stehbens, K. A. Loveland, S. Nichols, S. M. Donfield, T. S. Bell, S. D. Hill, and N. Amodei
Quantifying Practice Effects in Longitudinal Research With the WISC-R and WAIS-R: A Study of Children and Adolescents With Hemophilia and Male Siblings Without Hemophilia
J. Pediatr. Psychol., March 1, 2002; 27(2): 121 - 131.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
D. A. Pearson, N. M. McGrath, M. Nozyce, S. L. Nichols, C. Raskino, P. Brouwers, M. C. Lifschitz, C. J. Baker, J. A. Englund, and for the Pediatric AIDS Clinical Trials 152 St
Predicting HIV Disease Progression in Children Using Measures of Neuropsychological and Neurological Functioning
Pediatrics, December 1, 2000; 106(6): 76e - 76.
[Abstract] [Full Text]

Home page
 J Pediatr PsycholHome page
K. A. Loveland, J. A. Stehbens, E. M. Mahoney, P. A. Sirois, S. Nichols, J. D. Bordeaux, J. M. Watkins, N. Amodei, S. D. Hill, S. Donfield, et al.
Declining Immune Function in Children and Adolescents With Hemophilia and HIV Infection : Effects on Neuropsychological Performance
J. Pediatr. Psychol., July 1, 2000; 25(5): 309 - 322.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.