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Journal of Pediatric Psychiatry, Vol 24, 281-299, Copyright © 1999 by Society of Pediatric Psychology

ARTICLE

Review: emotional and behavioral functioning in phenylketonuria

JE Sullivan and P Chang
University of Minnesota, USA. jsulivan@enteract.com

OBJECTIVE: To examine 17 studies of the psychological sequelae of early- treated phenylketonuria (PKU) with emphasis on the impact of dietary control on functioning. Two questions are addressed: (1) What is the typical psychological profile associated with PKU? (2) Is emotional and behavioral disturbance more prevalent in PKU-affected individuals compared to appropriate controls? METHOD: Computerized searches of PsycINFO identified studies using behavioral, personality, and diagnostic measures. RESULTS: Findings converge upon a profile including attentional difficulties, depression, anxiety, and low self- esteem. Methodological constraints limit conclusions regarding the nature and severity of observed difficulties. A single study has used comparison groups appropriate for the simultaneous examination of the questions posed (Waisbren and Levy, 1991). CONCLUSIONS: We discuss results using a biopsychosocial framework, addressing the factors and processes that may influence emotional and behavioral functioning in this neurodevelopmental disorder. We outline potential lines of new investigation that address critical methodological factors.
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This article has been cited by other articles:


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 J Pediatr PsycholHome page
B. Lord, J. Ungerer, and C. Wastell
Implications of Resolving the Diagnosis of PKU for Parents and Children
J. Pediatr. Psychol., September 1, 2008; 33(8): 855 - 866.
[Abstract] [Full Text] [PDF]

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 J Pediatr PsycholHome page
J. E. Sullivan
Emotional Outcome of Adolescents and Young Adults With Early and Continuously Treated Phenylketonuria
J. Pediatr. Psychol., December 1, 2001; 26(8): 477 - 484.
[Abstract] [Full Text] [PDF]


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