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Journal of Pediatric Psychology, Vol. 25, No. 7, 2000, pp. 503-513
© 2000 Society of Pediatric Psychology

Neurocognitive Functioning and Magnetic Resonance Imaging in Children With Sickle Cell Disease

Ronald T. Brown, PhD1, Patricia C. Davis, MD2, Richard Lambert, PhD3, Lewis Hsu, MD, PhD2, Katharine Hopkins, MD2 and James Eckman, MD2

1 Medical University of South Carolina, 2 Emory University School of Medicine, 3 University of North Carolina at Charlotte

All correspondence should be sent to Ronald T. Brown, Department of Pediatrics, Medical University of South Carolina, 171 Ashley Avenue, P.O. Box 250561, Charleston, South Carolina 29425. E-mail: brownron{at}musc.edu .

Objective: To examine neurocognitive functioning in children classified with overt cerebral vascular accidents (CVAs), silent infarcts, or without central nervous system (CNS) pathology on magnetic resonance imaging.

Methods: Participants were 63 children and adolescents with sickle cell disease (SCD).

Results: Children with overt CVAs and silent infarcts differed from their peers without CNS pathology on measures of attention and executive functioning.

Conclusions: We consider these deficits the result of the high frequency of frontal lobe deficits incurred by children with SCD. Recommendations include the use of tests designed to measure attention and executive functioning as a way of screening children with SCD for possible CNS pathology. We also suggest that future research examine the mechanism underlying frontal lobe involvement for individuals with SCD.

Key words: sickle cell disease; neurocognitive; cerebral vascular accident; attention.


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