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Journal of Pediatric Psychology, Vol. 26, No. 8, 2001, pp. 477-484
© 2001 Society of Pediatric Psychology

Emotional Outcome of Adolescents and Young Adults With Early and Continuously Treated Phenylketonuria

Jill E. Sullivan, PhD

University of Minnesota

All correspondence should be sent to Jill E. Sullivan, Northwestern Memorial Hospital, Outpatient Treatment Center, 222 East Superior, 4th Floor, Chicago, Illinois 60611. E-mail: jzsulliv{at}nmh.org .

Objective: To assess the emotional functioning of adolescents and young adults with early and consistently treated phenylketonuria (PKU).

Methods: Twenty PKU-affected participants, ages 14-25, were compared with age-matched chronically ill (n = 17) and peer (n = 16) controls on a structured clinical interview, the Minnesota Multiphasic Personality Inventory, and the Tennessee Self-Concept Scale-2. Affected participants and nonparticipants were assessed using a multidomain assessment of functioning interview.

Results: There were no significant differences between groups for observable psychiatric disorders or emotional and functional symptoms. No significant differences were found in self-concept. Although there were no differences between groups for IQ or treatment variables, PKU-affected participants were more likely than nonparticipants to have sought help for psychological concerns.

Conclusions: Results suggest that early-treated PKU-affected adolescents and young adults do not show a higher risk for psychological disturbance than appropriate controls.

Key words: phenylketonuria; PKU; metabolic disorder; chronic illness; cystic fibrosis; juvenile onset diabetes; asthma; adolescents; young adults; emotional functioning; behavioral functioning.


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