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Journal of Pediatric Psychology, Vol. 27, No. 7, 2002, pp. 607-617
© 2002 Society of Pediatric Psychology

Predictors of PTSD in Mothers of Children Undergoing Bone Marrow Transplantation: The Role of Cognitive and Social Processes

Sharon Manne, PhD1, Katherine DuHamel, PhD2, Nancy Nereo, PhD2, Jamie Ostroff, PhD3, Susan Parsons, MD4, Richard Martini, MD5, Sharon Williams, PhD6, Laura Mee, PhD7, Sandra Sexson, MD7, Lisa Wu, MS2, Joanne Difede, PhD2 and William H. Redd, PhD2

1 Fox Chase Cancer Center, 2 Ruttenberg Cancer Center, Mt. Sinai School of Medicine, 3 Memorial Sloan-Kettering Cancer Center, 4 Dana Farber Cancer Institute, 5 Children's Memorial Hospital, Northwestern University Medical Center, 6 Packard Children's Hospital, Stanford University Medical Center, 7 Emory University Medical Center

All correspondence should be sent to Sharon Manne, Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, CPP Suite 1100, Philadelphia, Pennsylvania 19111. E-mail: SL_Manne{at}fccc.edu

Objective: To investigate the role of cognitive and social processing in posttraumatic stress symptoms and disorder (PTSD) among mothers of children undergoing bone marrow and hematopoietic stem-cell transplantation (BMT/SCT).

Method: Questionnaires assessing emotional distress, BMT-related fears, and negative responses of family and friends were completed by 90 mothers at the time of the BMT infusion and 3 and 6 months post-BMT. PTSD symptoms were measured 6 months post-BMT by both paper-and-pencil and structured interview methods.

Results: Emotional distress, BMT-related fears, and negative responses of family and friends assessed at the time of BMT hospitalization were predictive of later PTSD symptoms. None of these variables prospectively predicted a PTSD diagnosis as measured by the structured interview.

Conclusions: Higher levels of general psychological distress, cognitive interpretations of the threat of the BMT for the child's future functioning, and negative responses of family and friends may place mothers at risk for post-BMT posttraumatic stress symptomatology.

Key words: posttraumatic stress disorder; pediatric bone marrow transplantation; mothers; psychological distress.


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