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Journal of Pediatric Psychology Advance Access originally published online on May 4, 2005
Journal of Pediatric Psychology 2006 31(3):262-271; doi:10.1093/jpepsy/jsj014
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

The Impact on Health-Related Quality of Life from Non-Steroidal Anti-Inflammatory Drugs, Methotrexate, or Steroids in Treatment for Juvenile Idiopathic Arthritis

Russ Riddle, MS1, Christina N. Ryser, PhD1,2, Anne A. Morton, PhD1, J. D. Sampson, MA1, Richard H. Browne, PhD1, Marilynn G. Punaro, MD1,2 and Robert J. Gatchel, PhD2

1 Texas Scottish Rite Hospital for Children and 2 The University of Texas Southwestern Medical Center at Dallas

All correspondence concerning this article should be addressed to Russ Riddle, Department of Psychology, Texas Scottish Rite Hospital for Children, 2222 Welborn, Dallas, Texas 75219. E-mail: russ.riddle{at}tsrh.org.

Received April 19, 2004; revisions received October 20, 2004 and February 1, 2005; accepted February 9, 2005

Objective To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.

Key words: health-related quality of life; juvenile arthritis; outcomes.


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