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Journal of Pediatric Psychology Advance Access originally published online on April 18, 2007
Journal of Pediatric Psychology 2007 32(9):1111-1126; doi:10.1093/jpepsy/jsm012
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© The Author 2007. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Scholarly Literature Review: Management of Neurocognitive Late Effects with Stimulant Medication

Brian P. Daly, PhD and Ronald T. Brown, PhD

Temple University, Philadelphia

All correspondence concerning this article should be addressed to Brian P. Daly, PhD, Department of Public Health, Temple University, 3307 North Broad Street, Philadelphia, PA 19140. E-mail: brian.daly{at}temple.edu. The review of this manuscript was managed by John V. Lavigne, PhD


  Abstract

Objective To examine the extant literature on stimulant drug therapy for survivors of childhood cancer during the late-effects period. Methods A review of literature is provided on the mechanism of and cognitive toxicities for children and adolescents treated for acute lymphoblastic leukemia (ALL) and malignant brain tumors (BT) as well as the pharmacotherapy of stimulant medications, with a specific review of literature on the efficacy and safety of the stimulants for children with ALL and BT. Results Only four studies were found that have examined the effects of stimulant medication on the cognitive toxicities of childhood survivors of cancer during the late-effects period and only two of these investigations were controlled clinical trials. Findings suggest efficacy of the stimulants on parent and teacher ratings of attention and putative tasks of attention and executive functioning. Conclusions Although there is some preliminary support for the efficacy and safety of the stimulants for survivors of ALL and BT, more research is needed concerning the long-term effects of the stimulants among cancer survivors.

Key words: neurocognitive late effects; childhood cancer; stimulants; acute lymphoblastic leukemia; malignant brain tumors..

Received October 4, 2006; revision received January 15, 2007; accepted February 3, 2007


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