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Journal of Pediatric Psychology 4(1) pp. 67-76, 1979
© 1979 Society of Pediatric Psychology

research-article

A New Syndrome of Elevated Blood Lead and Microcephaly1

Donald K. Routh2,, Paul Mushak and Lois Boone

University of Iowa, University of North Carolina at Chapel Hill

2All correspondence should be addressed to Donald K. Routh, Department of Psychology, University of Iowa, Iowa City, Iowa 52242.

Blood lead level determinations were carried out on 100 children seen at an outpatient clinic for developmental and learning disabilities in a rural Southern state. One child with moderately elevated blood lead and nine with minimally elevated blood lead were identified; 7 of these 10 children were microcephalic, a markedly and significantly higher rate of microcephaly than in the remainder of the clinic sample. Most of the children suffering from the lead-microcephaly syndrome were Black, and a majority had birth weights under 2500 g, suggesting the possibility that prenatal exposure to lead might have caused their microcephaly and developmental handicaps.


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