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Journal of Pediatric Psychology Advance Access published online on November 26, 2008
Journal of Pediatric Psychology, doi:10.1093/jpepsy/jsn120
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Cognitive Development of Singletons Conceived by Intracytoplasmic Sperm Injection or In vitro Fertilization at Age 5 and 10 years

Lutz Goldbeck, PhD1, Friedrich Gagsteiger, MD2, Inge Mindermann1, Stefanie Ströbele1 and Yonca Izat, MD1

1Department of Child and Adolescent Psychiatry/Psychotherapy, University Ulm and 2IVF Centre Ulm

All correspondence concerning this article should be addressed to Lutz Goldbeck, Department of Child and Adolescent Psychiatry/Psychotherapy, University Ulm, Steinhoevelstr, 5 D-89075 Ulm, Germany. E-mail: lutz.goldbeck{at}uniklinik-ulm.de


  Abstract

Objective To investigate the cognitive functioning of low-risk singletons born after intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) at the age of 5 or 10 years. Methods Sixty-nine children (35 ICSI, 34 IVF) participated voluntarily in the study that had been approved by the local IRB. Their intellectual functioning was examined by the Kaufmann Assessment Battery for Children. Results The IQ of the study group fell in the normal range (mean = 98.2; SD = 12.2). ICSI children (IQ = 94.1, SD = 13.8) had statistically lower intellectual abilities compared to IVF children (IQ = 102.0, SD = 9.1; t = –2.81, p = .005), especially in simultaneous mental processing. 23.5% ICSI children, but only 2.9% IVF children (p = .011) had at least borderline delayed cognitive development. Conclusions Most artificially conceived singletons show a normal cognitive development, however the method of fertilization seems to have an impact on their IQ. ICSI might be associated with the risk for a slightly delayed cognitive development compared to IVF.

Key words: assisted reproduction; child follow-up; cognitive development; intracytoplasmic sperm injection; in vitro fertilization..

Received April 19, 2008; revision received October 22, 2008; accepted October 23, 2008


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