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Journal of Pediatric Psychology Advance Access published online on September 24, 2009
Journal of Pediatric Psychology, doi:10.1093/jpepsy/jsp078
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© The Author 2009. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Interaction of Child Maltreatment and 5-HTT Polymorphisms: Suicidal Ideation among Children from low-SES Backgrounds

Dante Cicchetti, PhD1, Fred A. Rogosch, PhD2, Melissa Sturge-Apple, PhD2 and Sheree L. Toth, PhD2

1Institute of Child Development, University of Minnesota and 2Mt. Hope Family Center, University of Rochester

All correspondence concerning this article should be addressed to Dante Cicchetti, PhD, McKnight Presidential Chair and Professor of Child Psychology and Psychiatry, Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA. E-mail: dcicchett{at}umn.edu


  Abstract

Objective To investigate whether genotypic variation of the serotonin transporter gene-linked promoter region (5-HTTLPR) moderates the effect of maltreatment on suicidal ideation in school-aged children. Methods Eight hundred and fifty low-income children (478 maltreated; 372 non-maltreated) provided DNA samples and self-reported depressive and suicidal symptoms. Genotypes of 5-HTTLPR (s/s or s/l vs. l/l) were determined by fragment analyses. Results Higher suicidal ideation was found among maltreated than non-maltreated children; the groups did not differ in 5-HTTLPR genotype frequencies. Children with one to two maltreatment subtypes and s/s or s/l genotypes had higher suicidal ideation than those with the l/l genotype; suicidal ideation did not differ in non-maltreated children or children with three to four maltreatment subtypes based on 5-HTTLPR variation. The results were applicable to emotionally maltreated/neglected and to physically/sexually abused children. Gene–environment interaction was not found for depressive symptoms. Conclusion The protective effect of the 5-HTTLPR l/l genotype on suicidal ideation was limited to maltreated children experiencing fewer subtypes.

Key words: suicidal ideation; child maltreatment; 5-HTTLPR; gene–environment interaction..

Received February 28, 2009; revision received July 9, 2009; accepted August 13, 2009


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