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Journal of Pediatric Psychology 2005 30(1):79-84; doi:10.1093/jpepsy/jsi018
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Journal of Pediatric Psychology vol. 30 no. 1 © Society of Pediatric Psychology 2005; all rights reserved.

Commentary: Study of the Neurobehavioral Consequences of Childhood Cancer: Entering the Genomic Era?

Pim Brouwers, PhD

Texas Children’s Cancer and Sickle Cell Centers, Baylor College of Medicine, Houston, Texas

All correspondence should be sent to Pim Brouwers, Texas Children’s Cancer & Sickle Cell Centers, Baylor College of Medicine, Houston, Texas 77030. E-mail: Brouwers@bcm.tmc.edu.

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The outlook for children diagnosed with cancer has significantly improved and continued to change since the late 1960s. Due to advances in therapy and diagnosis, the focus of psychological research and service has progressively changed from death and dying to surviving and cure, as well as possible neurobehavioral late effects, which is addressed in the accompanying papers (Moore; Butler & Mulhern, this issue).

The first papers addressing neurobehavioral issues of survivors of pediatric cancer focused on childhood acute lymphoblastic leukemia (ALL) and reported quite contrasting results. In the first study, Soni, Marten, Pitner, Duenas, and Powazek (1975)Go found that survivors of childhood ALL who had received central nervous system (CNS) preventative treatment, including 2400 cGy of cranial radiation therapy (CRT), did not have cognitive/intellectual deficits compared with a matched disease control group and were functioning in the average range. In another investigation, which studied similarly treated children, it was found . . . [Full Text of this Article]


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