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Journal of Pediatric Psychology 22(1) pp. 45-58, 1997
© 1997 Society of Pediatric Psychology

research-article

Variables Assoicated with Anticiplatory Nausea and Vomiting in Pediatric Cancer Patients Receiving Ondansetron Antiemetic Theraphy1

Vida L. Tyc2,, Raymond K. Mulhern, Deborah R. Barclay, Bruce F. Smith and Andrea A. Bieberich

St. Jude Children's Research Hospital and University of Tennessee School of Medicine Memphis, St. Jude Children’s Research Hospital Memphis

2All correspondence should be sent to Vida L. Tye, Division of Psychology, St. Jude Children's Research Hospital, 32 North Lauderdale, Memphis, Tennessee 38101ndash;0318

Investigated the prevalence of anticipatory nausea and vomiting (ANV) among 59 pediatric cancer patients who had routinely received ondansetron (Zofran®) antiemetic theraphy and determined patient–related factors associated with ANV. Of the sample, 59% indicated at least mild ANV symptoms, suggesting that a significant number of patients report ANV and are bothered by it, despite the use of Zofran. These children were compared to those reporting no ANV symptoms. Most ANV symptomatology was consistent with a traditional classical conditioning model although cognitive processes may also play a role. Children with greater expectations of severe postchemotherapy vomiting and those who were more distressed by nausea and vomiting were more likely to experience ANV symptoms. Implications for psychological and pharmacological treatments of ANV are discussed.

Key words: anticipatory nausea and vomiting; cancer; chemotherapy distress; antiemetic.


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