Journal of Pediatric Psychology 22(6) pp. 861-870, 1997
© 1997 Society of Pediatric Psychology
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Visual and Verbal Short-Term Memory Deficits in Childhood Leukemia Survivors After Intrathecal Chemotheraphy1
Clinical Neuroscience Laboratory, University of New Mexico, School of Medicine, University of New Mexico, Clinical Neuroscience Laboratory, University of New Mexico
2All correspondence should be sent to Kristina T. Ciesielski, Psychology Department, Logan Hall, University of New Mexico, Albuquerque. New Mexico 87131
Assessed survivors of childhood lymphoblastic leukemia (ALL) treated with intrathecal chemotherapy, using the Wide Range Assessment of Memory and Learning (WRAML), compared to controls without cancer, matched as closely as possible-in age, SES, and gender. Mild, but consistent, deficits were found in both visual-spatial and verbal single-trial memory tasks. In multitrial learning, only visual-spatial tasks resulted in deficient scores, while verbal learning was within the normal range. IQ results indicated scores 10–20 points lower in the ALL group. Memory results are related to deficits in strategic planning and attentional distractiveness. The WRAML may be a useful clinical tool to evaluate differential memory deficits in children with ALL.
Key words: acute lymphoblastic leukemia; intrathecal chemotherapy; single-trial visual-spatial and verbal memory; multitrial learning; WRAML.
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