Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Nichols, S.
Right arrow Articles by Amodei, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nichols, S.
Right arrow Articles by Amodei, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Pediatric Psychology, Vol. 25, No. 8, 2000, pp. 545-556
© 2000 Society of Pediatric Psychology

HIV-Associated Changes in Adaptive, Emotional, and Behavioral Functioning in Children and Adolescents With Hemophilia: Results From the Hemophilia Growth and Development Study

Sharon Nichols, PhD1, Elizabeth M. Mahoney, ScD2, Patricia A. Sirois, PhD3, Janice D. Bordeaux, PhD4, James A. Stehbens, PhD5, Katherine A. Loveland, PhD6, Nancy Amodei, PhD7 and the Hemophilia Growth and Development Study

1 University of California, San Diego, 2 Emory University, 3 Tulane University Medical Center, 4 Rice University, 5 University of Iowa College of Medicine, 6 University of Texas Medical School, Houston, 7 University of Texas Health Science Center, San Antonio

All correspondence should be sent to Sharon L. Nichols, Department of Neurosciences, Division of Pediatric Neurology, University of California, San Diego, 9500 Gilman Drive #0935, La Jolla, California 92093. E-mail: slnichols{at}ucsd.edu .

Objective: To assess changes in adaptive, emotional, and behavioral functioning over four years in children and adolescents with hemophilia and with or without HIV infection and to evaluate the relationship of these changes to immune status.

Methods: Participants were 277 HIV-seropositive and 126 HIV-seronegative boys with hemophilia. Participants with HIV infection were divided into three groups based on trajectory of immune functioning (CD4+ cell counts) over the course of the study. Caregivers completed the Vineland Adaptive Behavior Scales and Pediatric Behavior Scale (PBS).

Results: Results showed declining Vineland Communication scores for participants with consistently poor immune functioning. These participants also started with more PBS Attention Deficit and Deviation symptoms, which then decreased more sharply than for other groups. Low CD4+ counts were consistently associated with more Health and Depression-Anxiety symptoms on the PBS. However, with few exceptions, group means remained within normal limits.

Conclusions: According to their caregivers, boys with hemophilia and HIV infection showed considerable resilience with regard to adaptive behavior and emotional and behavioral problems. However, over time changes occurred in these areas that appear to be related to immune functioning.

Key words: HIV infection; pediatric AIDS; hemophilia; children and adolescents; adaptive functioning; behavior.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Pediatr PsycholHome page
S. D. Mayes, S. L. Calhoun, E. O. Bixler, A. N. Vgontzas, F. Mahr, J. Hillwig-Garcia, B. Elamir, L. Edhere-Ekezie, and M. Parvin
ADHD Subtypes and Comorbid Anxiety, Depression, and Oppositional-Defiant Disorder: Differences in Sleep Problems
J. Pediatr. Psychol., April 1, 2009; 34(3): 328 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J Pediatr PsycholHome page
J. D. Bordeaux, K. A. Loveland, D. Lachar, J. Stehbens, T. S. Bell, S. Nichols, N. Amodei, K. B. Adkins, and the Hemophilia Growth and Development Study
Hemophilia Growth and Development Study: Caregiver Report of Youth and Family Adjustment to HIV Disease and Immunologic Compromise
J. Pediatr. Psychol., April 1, 2003; 28(3): 175 - 183.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.