Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Knight, W. G.
Right arrow Articles by Kairam, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Knight, W. G.
Right arrow Articles by Kairam, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Pediatric Psychology, Vol. 25, No. 8, 2000, pp. 583-587
© 2000 Society of Pediatric Psychology

Brief Report

Effects of Pediatric HIV Infection on Mental and Psychomotor Development

Wanda Grant Knight, PhD1, Claude Ann Mellins, PhD2, Richard L. Levenson, Jr., PsyD2, Stephen M. Arpadi, MD3 and Ram Kairam, MD4

1 Boston University Medical Center, 2 HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, Columbia University, 3 St. Luke's/Roosevelt Hospital Center, 4 Bronx-Lebanon Hospital

All correspondence should be sent to Claude Ann Mellins, HIV Center for Clinical and Behavioral Studies, Box 15, 1051 Riverside Drive, New York, New York 10032. E-mail: cam14{at}columbia.edu .

Objective: To examine the effect of HIV status on infants' mental and psychomotor functioning, controlling for confounding factors such as prenatal drug exposure and birth conditions.

Methods: Twenty HIV-infected and 25 seroreverted infants (ages 3-30 months old) were administered the Bayley Scales of Infant Development (BSID) and a neurological examination at two time points, 4 to 12 months apart. The majority were from ethnic minority, socioeconomically disadvantaged families; 67% of the infants were prenatally drug-exposed.

Results: HIV-infected infants had significantly lower scores on the BSID at baseline (mental development) and follow-up (motor development) compared to seroreverters. When HIV and neurological deficits were considered together, HIV+ children with neurological deficits scored significantly lower than HIV+ children without neurological deficits and seroreverters, with and without neurological diagnoses. Prenatal drug exposure was not associated with performance on the BSID.

Conclusions: These data suggest that CNS involvement is a critical pathway by which HIV affects infants' neurodevelopment.

Key words: pediatric HIV/AIDS; cognitive development; psychomotor development; prenatal drug exposure; pediatric neurological dysfunction.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
A. Van Rie, A. Mupuala, and A. Dow
Impact of the HIV/AIDS Epidemic on the Neurodevelopment of Preschool-Aged Children in Kinshasa, Democratic Republic of the Congo
Pediatrics, July 1, 2008; 122(1): e123 - e128.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
M. C. Shanbhag, R. M. Rutstein, T. Zaoutis, H. Zhao, D. Chao, and J. Radcliffe
Neurocognitive Functioning in Pediatric Human Immunodeficiency Virus Infection: Effects of Combined Therapy
Arch Pediatr Adolesc Med, July 1, 2005; 159(7): 651 - 656.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. J. Jeremy, S. Kim, M. Nozyce, S. Nachman, K. McIntosh, S. I. Pelton, R. Yogev, A. Wiznia, G. M. Johnson, P. Krogstad, et al.
Neuropsychological Functioning and Viral Load in Stable Antiretroviral Therapy-Experienced HIV-Infected Children
Pediatrics, February 1, 2005; 115(2): 380 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A Stein, G Krebs, L Richter, A Tomkins, T Rochat, and M L Bennish
Babies of a pandemic
Arch. Dis. Child., February 1, 2005; 90(2): 116 - 118.
[Full Text] [PDF]

Home page
 NeurologyHome page
C. Macmillan, L.S. Magder, P. Brouwers, C. Chase, J. Hittelman, T. Lasky, K. Malee, C.A. Mellins, and J. Velez-Borras
Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women
Neurology, October 23, 2001; 57(8): 1402 - 1411.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.