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Journal of Pediatric Psychology, Vol. 27, No. 1, 2002, pp. 37-45
© 2002 Society of Pediatric Psychology

Methodological Issues in Outcome Studies of At-Risk Infants

Glen P. Aylward, PhD

School of Medicine, Southern Illinois University

All correspondence should be sent to Glen P. Aylward, SIU School of Medicine, Dept. of Pediatrics, P.O. Box 19658, Springfield, Illinois 62794-9658. E-mail: gaylward{at}siumed.edu .

Objective: To identify methodologic problems found in follow-up studies of infants at biologic and environmental risk and provide solutions and recommendations.

Methods: This article is a literature review.

Results: Problems fall into four groupings: (1) conceptualization/design issues, 2) subject population concerns, 3) procedural issues, and 4) measurement/outcome concerns.

Conclusions: Main-effect models are not useful; confounding and mediating variables must be identified. In addition, the following are needed: alternative analytic techniques, more precise subject selection and characterization of risk factors, geographically defined samples, broadened scope of outcome measures, and use of epidemiologic techniques.

Key words: developmental outcome; follow-up; high risk; infants; methodology.


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