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Journal of Pediatric Psychology 29(2) pp. 83-92, 2004
Journal of Pediatric Psychology vol. 29 no. 2 © Society of Pediatric Psychology 2004; all rights reserved

Relationship of Structural Magnetic Resonance Imaging, Magnetic Resonance Perfusion, and Other Disease Factors to Neuropsychological Outcome in Sickle Cell Disease

Royal Grueneich, PhD1, M. Douglas Ris, PhD2, William Ball, MD2, Karen A. Kalinyak, MD2, Robert Noll, PhD2, Kathy Vannatta, PhD2 and Robert Wells, MD2

1 Bangor, Maine, and 2 Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine

All correspondence concerning this article should be addressed to M. Douglas Ris, PhD., Division of Psychology, SEC-4, 3333 Burnet Ave., Cincinnati, Ohio 45229. E-mail: douglas.ris{at}cchmc.org.

Objective To investigate the relationship between neuropsychological functioning and radiographic findings in children with sickle cell disease (SCD) with no history of clinical neurological events. Methods Thirty-one patients with SCD randomly selected from a regional treatment center underwent neuropsychological and disease severity assessments. Of these, 22 also had structural magnetic resonance imaging and magnetic resonance perfusion studies performed. Results Forty-five percent of the imaged subgroup showed imaging abnormalities that were found to be correlated with disease severity but not neuropsychological level of performance indices. A significant relationship, however, was found between imaging abnormalities and increased variability in neuropsychological performance. Conclusions These results corroborate the high rate of rheologic and vascular pathology in SCD and underscore the importance of representing neuropsychological functioning in multiple ways.

Key words: sickle cell disease; neuropsychological functioning; imaging, disease severity.


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