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Journal of Pediatric Psychology Advance Access published online on March 3, 2005

Journal of Pediatric Psychology, doi:10.1093/jpepsy/jsi071
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Journal of Pediatric Psychology © The Author 2005. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org
Received February 19, 2004
Revised November 30, 2004
Accepted December 6, 2004

Article

Psychopathology in Children with Epilepsy: A Meta-Analysis

Roos Rodenburg MA1*, Geert Jan Stams PhD1, Anne Marie Meijer PhD1, Albert P. Aldenkamp PhD2, and Maja Dekovic PhD3

1 University of Amsterdam
2 University Hospital Maastricht; Department of Behavioral Sciences, Epilepsy Center Kempenhaeghe, and
3 Utrecht University

* To whom correspondence should be addressed.
Roos Rodenburg, E-mail: H.R.Rodenburg{at}uva.nl


   Abstract

Objective To examine the types and severity of psychopathology in children with epilepsy. Methods A series of meta-analyses were conducted to review 46 studies, including 2,434 children with epilepsy. Results Effect sizes were medium to large for comparisons with children from the general population, which indicates that children with epilepsy are at increased risk for psychopathology, including internalizing and externalizing behavior problems. Comparisons with children with another chronic illness revealed small to medium effect sizes, indicating that psychopathology in children with epilepsy may partly be attributed to chronicity of the disease. Attention problems, thought problems, and social problems proved to be relatively specific to epilepsy. Comparisons with siblings suggested that psychopathology in children with epilepsy may be associated with family factors, especially where behavioral disorders appear to be more generic. Conclusions Clinicians should consider both neurological and psychosocial factors, including the family system, when treating psychopathology in children with epilepsy.

Keywords: behavior problems; childhood epilepsy; family factors; meta-analysis; psychopathology.
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